Helping The others Realize The Advantages Of pkrrating
The interfacial residues are very conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements demonstrate which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations aid a model where activating RNA serves as being a scaffold to bind various PKR monomers, increasing